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That restriction hasnt appeared to stop people from using it the Wegovy pill is already estimated to be used by around 400,000 people in the US but it does make daily dosing more demanding for people with complex morning routines or medical regimens

Takeshita M, Banno Y, Nakamura M, et al

Dosing is always physician-directed and should never be self-adjusted

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Furthermore, the compelling clinical evidence confirming GLP 1 analogues cardiovascular benefits has fundamentally altered treatment guidelines, integrating these agents into cardiological practice